The Effect Consumption of Pre-Exercise Branched Chain Amino Acids Consumption With Vitamin E Supplementation on Muscular Damage

Background& purpose: Today, among athletes, the use of amino acid supplements with the aim of reducing muscle injuries is more important than in the past. the aim of this study was to survey the effect of branched chain amino acids (BCAA) consumption before exhaustive exercise along with 1-month vitamin E supplementation on lactate dehydrogenase (LDH) and creatine kinase (CK) levels of active females.   Methods: 32 active female students of Raazi University, with 18-23 years of age were selected based on the study eligibility criteria and after obtaining the informed consent form were divided into four groups of eight (placebo, Vit E, BCAA, and Vit E-BCAA), randomly. Vit E was consumed as 400 IU daily for a month and BCAA was consumed from 2.5 hours before exercise session in 4 bouts 30 minutes apart.   Exercise protocol was consisted of 30 minutes pedaling on ergometer with 50% of the aerobic power, and immediately continued with 75% of the aerobic power until the exhaustion. Sampling was done immediately and 48 hours after the exercise session and data were with Shapiro-Wilk tests, ANOVA repeated measurements, Bonferroni and Pearson correlation analyzed using SPSS 22 (α = 0.05). Results: none of supplements had effect on immediate levels of LDH and CK (P > .05) but the mean levels of LDH and CK, 48 hours post exercise was lower in BCAA (CK = 199.4 ± 11.00, LDH = 2.213 ± 23.44) and BCAA-Vit E (CK = 188.3 ± 3.20, LDH = 208.3 ± 40.12) compared to Vit E and placebo groups (P = .001) and the BCAA-Vit E showed lower levels that was negatively correlated to plasma [d1] leucine and isoleucine levels (P = .001). Conclusion: although BCAA alone decreased post exercise muscular damage indices, but it seems that leucine and isoleucine along with Vit E supplementation have more effect on muscular damage.  [d1]مثل فارسی تصحیح شود